Ultrafast Time-Resolved Study of Photophysical Processes of Beta-Lapachone


yzpmc - Posted on 29 October 2016

Project Description: 

The β-LA triplet can be quenched by amines, amino alcohols and alcohols to produce a semireduced radical (QH·), involving a H atom abstraction followed electron transfer-fast proton transfer steps. The QH· is toxic to a normal cell.
The β-LA triplet shows ππ* character with a lifetime about 5 μs.
The β-LA triplet can react with hydrogen donors, such as 2-propanol, 1,4-cyclohexadiene, 4-methoxyphenol and indole to form a ketyl radical.
The β-LA triplet can also be quenched by amino acids and nucleosides, such as 2’-deoxyguanosine (kq≈109 Lmol-1s-1).
We are going to use the DFT calculation to confirm the can be transition from β-lapachone to α-lapachone.

Research Project Details
Project Duration: 
11/2016 to 11/2018
Project Significance: 
Recent investigations suggest Beta-Lapachone's potential application against numerous diseases. Its lethality at micromolar (m) concentrations against a variety of cancer cells in culture indicates its potential against tumor growth. It is very meaningful to investigate the photophysical properties of Beta-Lapachone.
Results Achieved: 
We may use the DFT calculation to confirm the transition can be from β-lapachone to α-lapachone.