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Metagenomics Study of Individuals with Seasonal Influenza

yinpeng - Posted on 13 September 2016

Project Description: 

Background:
Influenza type A virus emerges seasonally across the world and has resulted in a pandemic as recent as 2009. It has been attributed to a substantial number of excess deaths among the elderly in Hong Kong (Wu et al. 2012). Despite the availability of seasonal influenza vaccination, the disease burden of the influenza virus for young children and the elderly remains substantial.

Purpose:
To characterize microbial communities at a functional and process-level in individuals with seasonal influenza type A before, during, and after an infection.
To discover new genes and pathways using samples from controls and individuals infected from shotgun sequencing microbiome.

Nature:
Analysis of genomics data

Researcher name: 
Yinpeng Wang
Researcher position: 
Graduate Student
Researcher department: 
School of Public Health
Researcher email: 
yinpeng@hku.hk
Research Project Details
Project Duration: 
09/2016 to 08/2018
Project Significance: 
The study will offer a great opportunity for understanding various complex microbial communities in the human body.
Remarks: 
Metagenomics technologies are needed in the project, which contains some key computational intensive steps, such as assembly, binning and annotation. Therefore, the HPC is involved in the project.