Test negative design study and misclassification error

Test negative design is a form of case-control study that is commonly adopted to estimate influenza vaccine effectiveness (VE), that measures the ability of vaccine to prevent outcomes of interest in the general population. VE is calculated by comparing occurrence of influenza among vaccinated and unvaccinated groups. However, the common practice to calculate VE has failed to take into account misclassification error of case and control, associated with delayed presentation to healthcare and therefore, delayed testing for influenza. This may result in a biased estimate of VE. This project aims to adjust for this form of misclassification error to better estimate VE using a Bayesian framework.